Figure 5
Numerical simulations of proliferating and non-proliferating cells in the absence and presence of HIA and CTA treatment with a slower decay rate of HIA and CTA effects. Simulations of the model show P versus t (bottom curve) and N versus t (top curve) in four cases. A. HIA and chemotherapy treatment are both absent (the control case). B. HIA is present and chemotherapy treatment in absent. C. HIA is absent and chemotherapy treatment is present. D. HIA and chemotherapy treatment are both present. In these simulations, the values of s1 and s2 were decreased from 0.2 to 0.1 (with all other parameter values as in Table 1). This causes the effect of HIA administration and CTA treatment on HSC levels to wear off more slowly as can be seen in comparison with Figure 3. Note that there is no change from Figure 3A to Figure 5A since in this case, HIA administration and CTA treatment are absent.