Figure 2

Estimating the antiviral effects of C-to-U mutation by APOBEC3G on HIV production. A) Mechanism of APOBEC3G inhibition in HIV replication. B) Quantification of antiviral effects of mutant APOBEC3G on HIV infection. HIV production reduces with increasing expression of APOBEC3G (dots: experimental data, solid lines: theoretical predictions, purple: WT APOBEC3G, blue: mutated APOBEC3G). Red dotted line shows the expected anti-HIV effect of C-to-U mutation activity, determined by Bliss independence.