Cardiac function of an example infarcted LV. Changes in EF (A) and SV (B) with the mean alignment angle of the collagen in scar tissue. Dotted lines are the baseline values corresponding to the healthy LV. Both EF and SV were maximized when collagen fibers were aligned longitudinally. The pressure volume relationships (C) show that SV is reduced through both reduced diastolic filling and a right shift in the ESPVR. Longitudinal alignment of fibers reduces both of these effects.