Table 1 Table of parameters: parameters used in simulations have been estimated based on the values introduced in following sources
From: Modeling drug resistance in a conjoint normal-tumor setting
Parameter | Units | Description | Estimated value | Reference source |
|---|---|---|---|---|
rT | Time−1 | Growth rate for the drug sensitive tumor cells | 0.3 | [31] |
KT | Cells | Carrying capacity of tumor cells | 1.2×106 | [31] |
β | Time−1 | Normal-tumor cell interaction rate | 1 | [31] |
ρ0 | Cells | Interaction clearance term | 1 | [31] |
ρ1 | Cells | Half-saturation for interaction | 1000 | [31] |
rN | Time−1 | Growth rate for the normal cells | 0.4 | [31] |
KN | Cells | Carrying capacity of normal cells | 106 | [31] |
κ | Time−1 | Tumor-normal cell interaction rate | 0–0.028 | [31] |
T* | Cells | Critical size of tumor | 3×105 | [31] |