Table 1 Pharmacokinetic and pharmacodynamic parameters for the PK-PD model. The volume of the effect compartment (Ve) was postulated to be either small (SMALL) or large (LARGE).
From: Volume of the effect compartment in simulations of neuromuscular block
Parameter | Unit | SMALL | LARGE | |
|---|---|---|---|---|
ED50 | mol·kg-1 | 2.2325·10-7 | ||
V1 | L·kg-1 | 0.0440 | 0.0434 | |
k10 | min-1 | 0.1847 | 0.1795 | |
k12 | min-1 | 0.3769 | 0.3574 | |
k21 | min-1 | 0.5587 | 0.7663 | |
k13 | min-1 | 0.4226 | 0.1981 | |
k31 | min-1 | 0.0909 | 0.0581 | |
kassoc | M-1·min-1 | 2.4·1010 | ||
{R}total | mol·kg-1 | 1.2921·10-10 | ||
Ve | L·kg-1 | 4.4·10-5 | 9.23·10-2 | |
ke1 | min-1 | 0.6159 | 0.1477 | |
[R]total | M | 2.9367·10-6 | 1.4·10-9 | |
Onset time | min | 4.50 |