Figure 6

Representative trajectories for 12 random walk simulations using only diffusion criteria (red and blue lines), compared to the movement of a signaling endosome within the same 500 millisecond time frame (green line). Parameters: 15 μm cell diameter, 5 μm nucleus diameter, 37°C, 500 msec, coefficient of diffusion as described in the text. Arrows along the plasma membrane surface denote the sites of signal initiation.