Skip to main content


Figure 9 | Theoretical Biology and Medical Modelling

Figure 9

From: Modeling the signaling endosome hypothesis: Why a drive to the nucleus is better than a (random) walk

Figure 9

A and B) Diffusion modeling incorporating dephosphorylation kinetics indicates substantial truncation of the root-mean-square (r.m.s.) displacement for STAT-3 diffusion (dashed red line compared to solid red line). This has the effect of reducing the crossing point at which signaling endosome transport (solid blue line) overcomes diffusion (ca. 2 μm for theoretical r.m.s. vs. transport reduced to ca. 200 nm for adjusted r.m.s. vs. transport). B shows same data as A at higher Y-axis magnification.

Back to article page