Figure 4

The predicted lipid-binding site of Talin. The coordinates of talin are displayed either in (I) isolation (1MIX); or (II), in a complex with an integrin beta3 tail fragment (residues 739–743) (1MIZ). The predicted lipid-binding sites are colored yellow and the integrin beta3 tail fragment gold. Amino and carboxyl termini are indicated in blue and red, respectively. (a) Ribbon model, (b) Space-filling representation, and (c) Electrostatic field potentials (orientation of the protein is identical to that viewed in (a) and (b)). The colors red, white and blue are used to indicate negative, neutral and positive field potentials (c), respectively.