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Table 1 Summary of experiments to determine the cross-sectional profile of impulse propagation in a bundle of cardiac fibers (20 × 10 model).

From: Propagation velocity profile in a cross-section of a cardiac muscle bundle from PSpice simulation

  No. of Gj-channels Rol2(KΩ) RBT(KΩ) Θ1(cm/sec) Θ10(cm/sec) Θ110Ratio Shape
A 0 200 200 36.6 17.0 2.15 Bell-shaped
B 1 200 200 36.8 19.7 1.86 Bell-shaped
C 10 200 200 46.6 44.6 1.04 Bullet-shaped
D 100 200 200 397 397 1.00 Flat
E 0 2000 200 32.9 29.0
#28.1
1.13
1.17
Accent bullet-shaped dimple
F 10 2000 200 46.6 44.6 1.04 Bullet-shaped
G 100 2000 200 397 397 1.00 Flat
H 0 2000 2000 62.2 32.9 1.89 Bell narrower and Θ approx doubled
I 100 2000 2000 386 397 0.97 Flat
J 0 20 200 38.1 14.4 2.65 Bell-shaped
K 0 20 20 13.0 14.4 0.90 Inverse
L 10 20 200 46.7 43.8 1.07 bell-shaped, but low ratio
M 100 20 200 397 397 1.00 Flat
N 0 50 200 37.4 15.4 2.43 Bell-shaped
O 0 800 200 35.1 22.7 1.55 Bell-shaped
  1. The gj-channels were inserted at the cell junctions of each chain.
  2. Θ1 ---- velocity at edge of bundle.
  3. Θ10 ---- velocity at middle of bundle.
  4. 20 × 10 model ---- 20 parallel chains of 10 cells each.
  5. All 20 cells at left end of bundle were stimulated simultaneously using rectangular current pulses of 0.25 nA and 0.25 ms duration.
  6. Bundle was symmetrical at the top and the bottom (including two grounds).
  7. All parameters were set at standard values, including Rjc of 25 MΩ (50 MΩ ÷ 2).
  8. Standard value for Rol2 was 200 KΩ, and for RBT was 200 KΩ.
  9. Voltage markers were placed only on cells 1, 5 and 10 of each chain (i.e., total of 60 traces).
  10. # This second value is for θ6 (also θ15), because this is where maximum slowing occurred (because of the dimple).