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Figure 5 | Theoretical Biology and Medical Modelling

Figure 5

From: Dynamically simulating the interaction of midazolam and the CYP3A4 inhibitor itraconazole using individual coupled whole-body physiologically-based pharmacokinetic (WB-PBPK) models

Figure 5

Mean ± standard deviation plots of the experimental observed plasma concentration time profiles for MDZ and the sum of its metabolites, 1OH-MDZ and 1OH-MDZ-Glu (symbols: squares) and the corresponding mean elimination optimized curves (solid lines) for the CYP3A5 genotypes, CYP3A5 *1/*1 (n = 6), CYP3A5 *1/*3 (n = 6) and CYP3A5*3/*3 (n = 7) in the basal state. Also presented is the mean ± standard deviation plots of the experimental observed plasma concentration time profiles for MDZ and the sum of its metabolites, 1OH-MDZ and 1OH-MDZ-Glu (symbols: circles) and the corresponding mean predicted curves (dotted lines) for the CYP3A5 genotypes in the CYP3A inhibited state resulting from ITZ administration. Plasma concentration time curves in the inhibited state were graphed starting at time = 0 to allow for direct comparison with the basal state curves. Experimental data was taken from Yu et al. [4].

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Theoretical Biology and Medical Modelling

ISSN: 1742-4682