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Modeling the effect of levothyroxine therapy on bone mass density in postmenopausal women: a different approach leads to new inference
Bedside diagnosis of osteoporotic constitution, real risk of inheriting ostoporosis, and finally osteoporosis
Sergio Stagnaro, Biophysical Semeiotics Research Laboratory
21 June 2007
Sirs,
To recognize women (and men, of course!) at high risk of osteoporosis we need first of all a bedside method, rapidly applicable on a very large scale, i.e. a method that relies on the assessment of “osteoporotic constitution” and inherited real risk of osteoporosis, based on microvascular remodelling, characterized by the newborn-pathological, type I, subtype (b), nonspecific, Endoarteriolar Blocking Devices described previously [1-5].
Clinical experience established over 51 years has allowed me to suggest such a clinical method as well as an original theory of the pathogenesis of osteoporosis as illustrated in previous papers (1, 3). A congenital functional mitochondrial cytopathology that I called Congenital Acidosic Enzyme-Metabolic Histangiopathy (CAEMH) [2, 6] also represents the conditio sine qua non of osteoporosis.
Moreover, all patients affected by impairment of collagen metabolism of whatever nature or location, including perivascular GAG, I found to be positive for this condition. Consequently, over the past 51 years, the mitochondrially-derived pathologies I have examined were or are CAEMH-altered cells, even from the functional viewpoint, due to low endocellular free energy. These become asocial elements, possibly causing the most common human disorders, including diabetes and cancer (2-6).
Interestingly, with the aid of the Biophysical Semiotics that I described previously (Bibliography in my website: www.semeioticabiofisica.it), doctors can easily recognize the inherited real risk of osteoporosis at the bedside and quantify it; it is always present in CAEMH-positive individuals, as well as in overt osteoporosis. Indeed, the original semiotics also allows doctors to diagnose osteoporosis at an early stage, i.e. osteoporotic constitution (ibidem). Biophysical Semeiotics, although very useful at the bedside, is unfortunately mainly overlooked. In a few words, from the practical viewpoint: in health, “mean” digital pressure, applied e.g. to the lumbar or caudal vertebrae (= spinal process), brings about the Aspecific Gastric Reflex after a latency of 8 s. (In the stomach both fundus and body are dilated, while the antral-pyloric region contracts). Interestingly, bone “preconditioning” (the doctor performs a second examination after exactly 5 s) brings about a favorable latency time: 16 sec. In contrast, in cases of osteoporotic constitution, real risk or osteoporosis, the basal latency time is < 8 s, the shortfall depending on the severity of the underlying disorder. Bone preconditioning appears to be pathological, i.e. shorter than the basal value. (www.semeioticabiofisica.it/Documenti/Eng/Precondizionamento%20semeiotico_eng.doc).
1) Stagnaro-Neri M, Stagnaro S: Diagnosi Clinica Precoce dell’Osteoporosi .Medlinecon la Percussione Ascoltata. Clin Ter 1991, 137:21 -27.
2) Stagnaro S, Stagnaro-Neri M: Una patologia mitocondriale ignorata: la Istangiopatia Congenita Acidosica Enzimo-Metabolica. Gazz Med It Arch Sci Med 149:67.
3) Stagnaro S, Stagnaro-Neri M: Le Costituzioni Semeiotico-Biofisiche.Strumento clinico fondamentale per la prevenzione primaria e la definizione della Single Patient Based Medicine. Roma: Ediz. Travel Factory; 2004. http://www.travelfactory.it/semeiotica_biofisica.htm
4) Stagnaro S., Stagnaro-Neri M. Single Patient Based Medicine.La Medicina Basata sul Singolo Paziente: Nuove Indicazioni della Melatonina. Ed. Travel Factory, Roma, 2005. http://www.travelfactory.it/libro_singlepatientbased.htm
5) Stagnaro S: Newborne-pathological Endoarteriolar Blocking Devices in Diabetic and Dislipidaemic Constitution and Diabetes Primary Prevention. Lancet 2007, March 06. Pg 1. http://www.thelancet.com/journals/lancet/article/PIIS0140673607603316/comments?totalcomments=1
6) Stagnaro S, West PJ, Hu FB, Manson JE, Willett WC: Diet and Risk of Type 2 Diabetes. N Engl J Med 2002, 346:297-298. [Medline]
Theoretical Biology and Medical Modelling
Bedside diagnosis of osteoporotic constitution, real risk of inheriting ostoporosis, and finally osteoporosis
21 June 2007
Sirs,
To recognize women (and men, of course!) at high risk of osteoporosis we need first of all a bedside method, rapidly applicable on a very large scale, i.e. a method that relies on the assessment of “osteoporotic constitution” and inherited real risk of osteoporosis, based on microvascular remodelling, characterized by the newborn-pathological, type I, subtype (b), nonspecific, Endoarteriolar Blocking Devices described previously [1-5].
Clinical experience established over 51 years has allowed me to suggest such a clinical method as well as an original theory of the pathogenesis of osteoporosis as illustrated in previous papers (1, 3). A congenital functional mitochondrial cytopathology that I called Congenital Acidosic Enzyme-Metabolic Histangiopathy (CAEMH) [2, 6] also represents the conditio sine qua non of osteoporosis.
Moreover, all patients affected by impairment of collagen metabolism of whatever nature or location, including perivascular GAG, I found to be positive for this condition. Consequently, over the past 51 years, the mitochondrially-derived pathologies I have examined were or are CAEMH-altered cells, even from the functional viewpoint, due to low endocellular free energy. These become asocial elements, possibly causing the most common human disorders, including diabetes and cancer (2-6).
Interestingly, with the aid of the Biophysical Semiotics that I described previously (Bibliography in my website: www.semeioticabiofisica.it), doctors can easily recognize the inherited real risk of osteoporosis at the bedside and quantify it; it is always present in CAEMH-positive individuals, as well as in overt osteoporosis. Indeed, the original semiotics also allows doctors to diagnose osteoporosis at an early stage, i.e. osteoporotic constitution (ibidem). Biophysical Semeiotics, although very useful at the bedside, is unfortunately mainly overlooked. In a few words, from the practical viewpoint: in health, “mean” digital pressure, applied e.g. to the lumbar or caudal vertebrae (= spinal process), brings about the Aspecific Gastric Reflex after a latency of 8 s. (In the stomach both fundus and body are dilated, while the antral-pyloric region contracts). Interestingly, bone “preconditioning” (the doctor performs a second examination after exactly 5 s) brings about a favorable latency time: 16 sec. In contrast, in cases of osteoporotic constitution, real risk or osteoporosis, the basal latency time is < 8 s, the shortfall depending on the severity of the underlying disorder. Bone preconditioning appears to be pathological, i.e. shorter than the basal value. (www.semeioticabiofisica.it/Documenti/Eng/Precondizionamento%20semeiotico_eng.doc).
1) Stagnaro-Neri M, Stagnaro S: Diagnosi Clinica Precoce dell’Osteoporosi .Medlinecon la Percussione Ascoltata. Clin Ter 1991, 137:21 -27.
2) Stagnaro S, Stagnaro-Neri M: Una patologia mitocondriale ignorata: la Istangiopatia Congenita Acidosica Enzimo-Metabolica. Gazz Med It Arch Sci Med 149:67.
3) Stagnaro S, Stagnaro-Neri M: Le Costituzioni Semeiotico-Biofisiche.Strumento clinico fondamentale per la prevenzione primaria e la definizione della Single Patient Based Medicine. Roma: Ediz. Travel Factory; 2004. http://www.travelfactory.it/semeiotica_biofisica.htm
4) Stagnaro S., Stagnaro-Neri M. Single Patient Based Medicine.La Medicina Basata sul Singolo Paziente: Nuove Indicazioni della Melatonina. Ed. Travel Factory, Roma, 2005. http://www.travelfactory.it/libro_singlepatientbased.htm
5) Stagnaro S: Newborne-pathological Endoarteriolar Blocking Devices in Diabetic and Dislipidaemic Constitution and Diabetes Primary Prevention. Lancet 2007, March 06. Pg 1. http://www.thelancet.com/journals/lancet/article/PIIS0140673607603316/comments?totalcomments=1
6) Stagnaro S, West PJ, Hu FB, Manson JE, Willett WC: Diet and Risk of Type 2 Diabetes. N Engl J Med 2002, 346:297-298. [Medline]
Competing interests
None declared