Table 2 Extended E-D model of breast cancer and prostate cancer
From: Can a single model explain both breast cancer and prostate cancer?
Hormone receptor | Property |
|---|---|
Membrane androgen receptor | ↑apoptotic proteins ↓bcl-2 (BC only) ↑bcl-2 (PC only) ↓AS3 ↑Ca++ influx |
Intracellular androgen receptor | ↓apoptotic proteins ↓bcl-2 ↑AS3 ↓Ca++ influx ↑calreticulin |
Estrogen receptor-αβ heterodimer | ↑telomerase activity (PC only) |
Estrogen receptor-α homodimer | ↑telomerase activity |
Estrogen receptor-α | ↑bcl-2 |
Estrogen receptor-β | ↓bcl-2 |
Membrane estrogen receptor | ↑bcl-2 |
Progesterone receptor A | ↑bcl-2 |
Progesterone receptor B | ↓bcl-2 |
Membrane progesterone receptor | ↓bcl-2 |