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Figure 4 | Theoretical Biology and Medical Modelling

Figure 4

From: A unified framework of immunological and epidemiological dynamics for the spread of viral infections in a simple network-based population

Figure 4

The transmission of virus across the population differs for variations in the connectivity coefficient, ω i . (A) Higher values of the connectivity coefficient (ω i = 1.0 × 10-3) shortened the time required to spread the disease through the population, as well as the peak of the outbreak (blue line). Lower values of the connectivity coefficient (ω i = 1.0 × 10-4 and 1.0 ×10-5) had the opposite effect (red and yellow lines, respectively). (B) Both high and low values of ω i demonstrated no apparent sizeable relationship with the accumulated viral load in the population (colour code the same as 3A). For scenarios (A and B) a person's immune responsiveness was randomly determined from a random normal distribution with μ = 0.063 and σ = 0.0225 (see Methods for further details). For scenarios (C and D), immune responsiveness for fixed values of c i = 0.1 and 0.016 were combined in simulations with different fixed values of ω i = 1.0 × 10-3 and 1.0 × 10-5. The colour code is the same for 3A.

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