Table 1 Kinetic equations and initial concentrations. See Table 2 for references.
From: Simulating non-small cell lung cancer with a multiscale agent-based model
Reactant | Molecular variable | Initial concentration [nM] | ODE |
|---|---|---|---|
X 1 | EGF | to be varied | d(X1)/dt = -v1 |
X 2 | EGFR | 80 | d(X2)/dt = -v1 |
X 3 | EGF-EGFR | 0 | d(X3)/dt = v1 - 2v2 |
X 4 | (EGF-EGFR)2 | 0 | d(X4)/dt = v2 + v4 - v3 |
X 5 | EGF-EGFR-P | 0 | d(X5)/dt = v3 + v7 - v4 - v5 |
X 6 | PLCγ | 10 | d(X6)/dt = v8 - v5 |
X 7 | EGF-EGFR-PLCγ | 0 | d(X7)/dt = v5 - v6 |
X 8 | EGF-EGFR-PLCγ-P | 0 | d(X8)/dt = v6 - v7 |
X 9 | PLCγ-P | 0 | d(X9)/dt = v7 - v8 - v9 - v10 |
X 10 | PLCγ-P-I | 0 | d(X10)/dt = v9 |
X 11 | PKC | 10 | d(X11)/dt = -v10 |
X 12 | PKC* | 0 | d(X12)/dt = v10 - v11 |
X 13 | Raf | 100 | d(X13)/dt = -v11 |
X 14 | Raf* | 0 | d(X14)/dt = v11 - v12 - v14 |
X 15 | MEK | 120 | d(X15)/dt = v13 - v12 |
X 16 | MEK-P | 0 | d(X16)/dt = v12 + v15 - v13 - v14 |
X 17 | MEK-PP | 0 | d(X17)/dt = v14 - v15 - v16 - v18 |
X 18 | ERK | 100 | d(X18)/dt = v17 - v16 |
X 19 | ERK-P | 0 | d(X19)/dt = v16 + v19 - v17 - v18 |
X 20 | ERK-PP | 0 | d(X20)/dt = v18 - v19 |