Figure 2

Multiple scales of Biological Organization, Biomedical Research and Multi-scale ABM Architecture. Representation of the multiple scales of biological organization and the ABM architecture in a nested fashion, to reflect the reliance of the higher scale behavior on the mechanisms operating at the lower levels. Of note, the biomedical research community structure in the middle is not so represented, to reflect the relative compartmentalization of the community with respect to the operational aspect of research, though obviously lower scale knowledge and information does influence the hypotheses generated and being tested at the higher scale.