Figure 7

Simulated Permeability Effects of Ethyl Pyruvate and NAD⁺. Graph demonstrating the effects of simulated addition of ethyl pyruvate and NAD⁺ on the pro-inflammatory algorithms within the epi-cell agents. Both of these substances interfere with NF-kappa-B localization, and therefore are "upstream" from the iNOS-NO pathways as represented in those rules. This graph can be compared to Figure 1 from Ref [24] with ethyl pyruvate at 1.0 mM dose, and Figure 1a from Ref [25] with NAD⁺ at 0.1 mM dose.