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Figure 1 | Theoretical Biology and Medical Modelling

Figure 1

From: Feature context-dependency and complexity-reduction in probability landscapes for integrative genomics

Figure 1

Investigating context-dependency. Point-wise comparison at a given genome location (the box underlines the location n+2) of probability profiles of a feature X obtained in condition B and under various additional prescriptions C i (i = 1, 2, 3) with the joint profile constructed from the pooled data. We have denoted in short P n ( i ) = P n ( X | B , C i ) MathType@MTEF@5@5@+=feaagaart1ev2aaatCvAUfKttLearuWrP9MDH5MBPbIqV92AaeXatLxBI9gBaebbnrfifHhDYfgasaacPC6xNi=xH8viVGI8Gi=hEeeu0xXdbba9frFj0xb9qqpG0dXdb9aspeI8k8fiI+fsY=rqGqVepae9pg0db9vqaiVgFr0xfr=xfr=xc9adbaqaaeGaciGaaiaabeqaaeqabiWaaaGcbaGaemiuaa1aa0baaSqaaiabd6gaUbqaaiabcIcaOiabdMgaPjabcMcaPaaakiabg2da9iabdcfaqnaaDaaaleaacqWGUbGBaeaacqGGOaakcqWGybawcqGG8baFcqWGcbGqcqGGSaalcqWGdbWqdaWgaaadbaGaemyAaKgabeaaliabcMcaPaaaaaa@3E62@ and P P n ( i ) = P P n ( X | B , C i ) MathType@MTEF@5@5@+=feaagaart1ev2aaatCvAUfKttLearuWrP9MDH5MBPbIqV92AaeXatLxBI9gBaebbnrfifHhDYfgasaacPC6xNi=xH8viVGI8Gi=hEeeu0xXdbba9frFj0xb9qqpG0dXdb9aspeI8k8fiI+fsY=rqGqVepae9pg0db9vqaiVgFr0xfr=xfr=xc9adbaqaaeGaciGaaiaabeqaaeqabiWaaaGcbaGaemiuaa1aa0baaSqaaiabdcfaqnaaBaaameaacqWGUbGBaeqaaaWcbaGaeiikaGIaemyAaKMaeiykaKcaaOGaeyypa0Jaemiuaa1aa0baaSqaaiabdcfaqnaaBaaameaacqWGUbGBaeqaaaWcbaGaeiikaGIaemiwaGLaeiiFaWNaemOqaiKaeiilaWIaem4qam0aaSbaaWqaaiabdMgaPbqabaWccqGGPaqkaaaaaa@4124@ the 'probabilities of probability', i.e. the functional distributions describing the estimated variability of the distributions P n ( i ) MathType@MTEF@5@5@+=feaagaart1ev2aaatCvAUfKttLearuWrP9MDH5MBPbIqV92AaeXatLxBI9gBaebbnrfifHhDYfgasaacPC6xNi=xH8viVGI8Gi=hEeeu0xXdbba9frFj0xb9qqpG0dXdb9aspeI8k8fiI+fsY=rqGqVepae9pg0db9vqaiVgFr0xfr=xfr=xc9adbaqaaeGaciGaaiaabeqaaeqabiWaaaGcbaGaemiuaa1aa0baaSqaaiabd6gaUbqaaiabcIcaOiabdMgaPjabcMcaPaaaaaa@319D@ . The comparison aims at determining whether the conditions C i provide additional information on X and decrease its indeterminacy or whether they can be ignored and the analysis performed on the pooled data. Essential conditions define the 'context' of the feature X.

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