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Figure 5 | Theoretical Biology and Medical Modelling

Figure 5

From: Feature context-dependency and complexity-reduction in probability landscapes for integrative genomics

Figure 5

Feature probability quality profile construction for experimental data. The set of conditions that are essential for feature X are determined hierarchically, either by considering more detailed prescriptions (additional disjoint conditions (C i ) i ) corresponding to a partition of the data in constructing the conditional profiles, or in aggregating the conditions if the conditions (C i ) i have no impact on the feature. This procedure can be performed recursively. Once sub-conditions have been collapsed to a biological condition, the biological condition can be compared using the same logic to the next higher level biological condition. Please note that for reasons of simplicity we only consider the two immediately concerned levels explicitly in the notation. Imagine for instance data pertaining to the transcriptome of different types of blood cells (C i ) i . One might want to consider every cell type individually, or the red and white blood cells (B1, B2) jointly or the entire compartment (B0).

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