Transient antiretroviral therapy selecting for common HIV-1 mutations substantially accelerates the appearance of rare mutations

Table 1 Model parameters

Symbol	Description	Value	Source
μ _T	natural healthy cell death rate	0.02 day^-1	[40–50 days] [19]
μ _P	productively infected cell death rate	0.5 day^-1	[1–2 days] [20]
S _T	supply rate of target cells	2 × 10⁸ cells day^-1	Estimated
k _i	viral strain infectivity	varies	Estimated
ε ₂₁	single-point mutation rate	2.5 × 10^-5	see Appendix
f	probability of error free transcription	0.37	Implied by ε₂₁

ISSN: 1742-4682