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Table 1 Species description, synthesis and degradation rates for the model equations

From: Construction and analysis of a modular model of caspase activation in apoptosis

Species Description Synthesis rate (nM/s) Degradation rate (s-1)
DISC DISC   8.807 × 10-3
Casp8 procaspase-8 adjusted 6.5 × 10-5 [65]
Casp8* caspase-8   9.667 × 10-5 [65]
Casp3 procaspase-3 adjusted 6.5 × 10-5 [65]
Casp3* caspase-3   9.667 × 10-5 [65]
XIAP XIAP adjusted 1.933 × 10-4 [65]
Casp3*-XIAP Casp3*-XIAP complex   2.883 × 10-4 [65]
BAR BAR 1.111 × 10-3 ([BAR]0 = 66.67 nM [65]) 1.667 × 10-5 [65]
Casp8*-BAR Casp8*-BAR complex   1.933 × 10-4 [65]
Bid Bid 4.168 × 10-4 ([Bid]0 = 25 nM [70, 71]) 1.667 × 10-5 (μBAR)
tBid truncated Bid   1.667 × 10-5 (μBid)
tBid-Bax2 tBid-Bax2 complex   0.0264
Cytc cytochrome c (mitochondrial) 10-3 ([Cytc]0 = 100 nM [70, 71]) 10-5
Cytc* cytochrome c (cytosolic)   10-5
Smac Smac (mitochondrial) 0.0167 ([Smac]0 = 100 nM [70, 71]) 1.667 × 10-5 (μBAR)
Smac* Smac (cytosolic)   1.667 × 10-5 (μSmac)
Smac*-XIAP Smac-XIAP complex   1.933 × 10-4 (μCasp8*-BAR)
Apop apoptosome   1.487 × 10-5
Casp9 procaspase-9 1.3 × 10-3 ([Casp9]0 = 20 nM [70, 71]) 6.5 × 10-5 (μCasp8)
Casp9* caspase-9   9.667 × 10-5 (μCasp8*)
Casp9*-XIAP Casp9*-XIAP complex   2.883 × 10-4 (μCasp3*-XIAP)
  1. Model species and description are given. In the model, synthesis and degradation rates are given for the model system and labeled α and μ, respectively.