Construction and analysis of a modular model of caspase activation in apoptosis

Table 4 Initial conditions for the model variables and oligomerization parameters

	Initial concentration (nM)
Species	HeLa	Jurkat T	Parameter	Value
Casp8	216.67 [65]	33.33 [70, 71]	[FasL]₀	2 nM [70, 71]
Casp3	35 [65]	200 [70, 71]	[FasR]₀	10 nM [70, 71]
XIAP	66.67 [65]	30 [70, 71]	K _DISC	1.032 nM [70, 71]
BAR	66.67 [65]	66.67 [65]	[Bax]₀	83.33 nM [70, 71]
Bid	25 [70, 71]	25 [70, 71]	$K tBid-Bax 2 MathType@MTEF@5@5@+=feaagaart1ev2aaatCvAUfKttLearuWrP9MDH5MBPbIqV92AaeXatLxBI9gBaebbnrfifHhDYfgasaacPC6xNi=xH8viVGI8Gi=hEeeu0xXdbba9frFj0xb9qqpG0dXdb9aspeI8k8fiI+fsY=rqGqVepae9pg0db9vqaiVgFr0xfr=xfr=xc9adbaqaaeGaciGaaiaabeqaaeqabiWaaaGcbaGaem4saS0aaSbaaSqaaiabbsha0jabbkeacjabbMgaPjabbsgaKjabb2caTiabbkeacjabbggaHjabbIha4naaBaaameaacqaIYaGmaeqaaaWcbeaaaaa@3818@$	100 nM [70, 71]
Cytc	100 [70, 71]	100 [70, 71]	[Apaf]₀	100 nM [70, 71]
Smac	100 [70, 71]	100 [70, 71]	λ _Apop	1 [75]
Casp9	20 [70, 71]	20 [70, 71]

Initial conditions of model variables are given. Some species initial conditions differ between HeLa or Jurkat T cell type. Parameters and values are given for steady-state oligomerization modules.

ISSN: 1742-4682