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Table 4 Initial conditions for the model variables and oligomerization parameters

From: Construction and analysis of a modular model of caspase activation in apoptosis

  Initial concentration (nM)   
Species HeLa Jurkat T Parameter Value
Casp8 216.67 [65] 33.33 [70, 71] [FasL]0 2 nM [70, 71]
Casp3 35 [65] 200 [70, 71] [FasR]0 10 nM [70, 71]
XIAP 66.67 [65] 30 [70, 71] K DISC 1.032 nM [70, 71]
BAR 66.67 [65] 66.67 [65] [Bax]0 83.33 nM [70, 71]
Bid 25 [70, 71] 25 [70, 71] K tBid-Bax 2 MathType@MTEF@5@5@+=feaagaart1ev2aaatCvAUfKttLearuWrP9MDH5MBPbIqV92AaeXatLxBI9gBaebbnrfifHhDYfgasaacPC6xNi=xH8viVGI8Gi=hEeeu0xXdbba9frFj0xb9qqpG0dXdb9aspeI8k8fiI+fsY=rqGqVepae9pg0db9vqaiVgFr0xfr=xfr=xc9adbaqaaeGaciGaaiaabeqaaeqabiWaaaGcbaGaem4saS0aaSbaaSqaaiabbsha0jabbkeacjabbMgaPjabbsgaKjabb2caTiabbkeacjabbggaHjabbIha4naaBaaameaacqaIYaGmaeqaaaWcbeaaaaa@3818@ 100 nM [70, 71]
Cytc 100 [70, 71] 100 [70, 71] [Apaf]0 100 nM [70, 71]
Smac 100 [70, 71] 100 [70, 71] λ Apop 1 [75]
Casp9 20 [70, 71] 20 [70, 71]   
  1. Initial conditions of model variables are given. Some species initial conditions differ between HeLa or Jurkat T cell type. Parameters and values are given for steady-state oligomerization modules.
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Theoretical Biology and Medical Modelling

ISSN: 1742-4682