Figure 8
From: Antimicrobial breakpoint estimation accounting for variability in pharmacokinetics
Robustness of weighted AUC method. Left panel represents the three most widely used efficacy functions E: solid line for the linear function, broken line for the Emax function and dotted line for the logistic function. The corresponding AUCW are plotted in the right panel with respect to concentration, along with AUC (solid thick line). The difference in AUCW value estimated for these three efficacy functions is negligible compared to the differences from AUC.