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Table 1 Steady-state concentrations of selected components in the Lee-Heinrich and modified models

From: Examination of effects of GSK3β phosphorylation, β-catenin phosphorylation, and β-catenin degradation on kinetics of Wnt signaling pathway using computational method

 

Concentration (nM)

component

Lee-Heinrich model

modified model

Fold change

Dsha

0

0

 

(APC*/axin*/GSK3β)

0.00966

0.004742

0.491

(APC/axin/GSK3β)

0.00483

0.002362

0.489

(β-catenin*/APC*/axin*/GSK3β)

0.00202

0.001991

0.986

β-catenin*

1.00

0.983341

0.983

β-catenin

25.1

50.3766

2.007

Axin

0.000493

0.000492

0.998

GSK3β

50

25

0.500

GSK3β*

 

25

 

β-catenin+

 

5.03766

 
  1. (see text for description).
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Theoretical Biology and Medical Modelling

ISSN: 1742-4682