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Table 1 Steady-state concentrations of selected components in the Lee-Heinrich and modified models

From: Examination of effects of GSK3β phosphorylation, β-catenin phosphorylation, and β-catenin degradation on kinetics of Wnt signaling pathway using computational method

  Concentration (nM)
component Lee-Heinrich model modified model Fold change
Dsha 0 0  
(APC*/axin*/GSK3β) 0.00966 0.004742 0.491
(APC/axin/GSK3β) 0.00483 0.002362 0.489
(β-catenin*/APC*/axin*/GSK3β) 0.00202 0.001991 0.986
β-catenin* 1.00 0.983341 0.983
β-catenin 25.1 50.3766 2.007
Axin 0.000493 0.000492 0.998
GSK3β 50 25 0.500
GSK3β*   25  
β-catenin+   5.03766  
  1. (see text for description).