Figure 6

Prediction of tissue concentration of domperidone in WT (black line) and KO (black dashed line) mice using the mechanistic transport based tissue model with passive and P-gp mediated efflux transports for heart and brain. Tissue concentration measured in WT mice (black lozenge) and KO mice (black circle) after IV administration of 5 mg/kg of domperidone. BLQ = Below Limit of Quantification.