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Figure 7 | Theoretical Biology and Medical Modelling

Figure 7

From: Homeostatic mechanisms in dopamine synthesis and release: a mathematical model

Figure 7

Time courses of eda Panel A shows time courses of eda after a pulse of stimulation for DAT-tg, WT, DAT+/-, and DAT-/- mice. The data for DAT-tg mice is taken from figure four B of [74] rescaled to have the same relationship to WT as in that paper. The data on WT, DAT+/-, and DAT-/- mice are from figure one of [24]. Panel B shows the time course of eda in the model in response to a 300 msec pulse during which the release coefficient fire is raised from 1/hr to 900/hr (see Methods) for DAT-tg, WT, DAT+/-, and DAT-/- mice. The V max of the DATs is raised 50% for DAT-tg mice, lowered 50% for DAT+/- mice, and set to zero for DAT-/- mice. The K m of the DATs is 0.2 μ M. The peaks gets smaller as one moves from DAT-tg to WT to DAT+/-. Panel C shows the time course of eda in the model in response to a 300 msec pulse during which the release coefficient fire is raised from 1/hr to 90/hr (see Methods) for DAT-tg, WT, DAT+/-, and DAT-/- mice. The V max values are as in Panel B and the K m of the DATs is 0.2 μ M. The peaks now increase as one goes from DAT-tg to WT to DAT+/-. Note how narrow the peaks are because the concentrations are lower and the DATs are not saturated. Panel D shows the time course of eda in the model in response to a 300 msec pulse during which the release coefficient fire is raised from 1/hr to 900/hr (see Methods) for DATg, WT, DAT+/-, and DAT-/- mice. The V max vales are as in Panel B. The K m of the DATs is raised to 1.6 μ M. The Dat-tg and DAT+/- peaks are both lower than the WT peak as in the experimental data in Panel A.

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