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Figure 8 | Theoretical Biology and Medical Modelling

Figure 8

From: Homeostatic mechanisms in dopamine synthesis and release: a mathematical model

Figure 8

Denervation affects the peaks of eda in the striatum. Panels A and C show data and regression lines redrawn from [46], figure 3(a), three (b). In both experiments and the model, tissue dopamine concentration as a percentage of normal is approximately equal to f, the fraction of terminals still alive. At 20 Hz stimulation, both the experimental data (Panel A) and the model (Panel B) show that the peaks keep their heights until f is very small. This "passive stabilization" is the main focus of [46] and [22]. However, at 60 Hz stimulation, the eda peaks decline linearly as f declines from one to zero both experimentally (Panel C) and in the model (Panel D).

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