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Table 2 Kinetic Parameters (μ M, μ M/hr,/hr).

From: Homeostatic mechanisms in dopamine synthesis and release: a mathematical model

velocity parameter model value literature value references
V AADC aromatic amino acid decarboxylase
  K m 130 130 [94]
  V max 10,000   *
V DAT dopamine transporter
  K m .2 0.2-2 [75, 76]
  V max 8000   *
V DRR dihydropteridine reductase
  K bh 2 100 4-754 [95, 96]
  K NADPH 75 29-770 [7080, 9799]
  200   *
  K bh 4 10 1.1-17 [100, 98]
  K NADP 75 29-770 [7080, 9799]
  80   *
V MAT vesicular monoamine transporter
  K m 3 .2-10 [101103]
  V max 7082   *
  k out 40   *
V TH tyrosine hydroxylase
  K tyr 46 46 [60]
  K bh 4 60 13, [60]
  V max 125   *
  K i (cda) 110 110 [104]
  K i (substrate inhibition) 160 46 [23, 60] ;160
  K i (autoreceptors)    *
V TYRin neutral amino acid transporter
  K m 64 64 [51]
  V max 400   *
tyrtyrpool
  k 1 6   *
  k -1 0.6   *
catabolism and diffusion
  0.2   *
  10   *
  30   *
  3 3.3 [68]
  3.45 3.45 [69, 70]
  0.2   *
  k rem 400   *
  1. * see text