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Figure 3 | Theoretical Biology and Medical Modelling

Figure 3

From: Computational investigation of epithelial cell dynamic phenotype in vitro

Figure 3

ISEA2 CELL decision logic and axiomatic operating principles. Simulation time advances by simulation cycles. During a simulation cycle, every CULTURE component is given an opportunity to update. Every CELL in a pseudo-random order decides what action to take based on its internal state (POLARIZED or UNPOLARIZED) and the composition of its adjacent neighborhood. Actions available to UNPOLARIZED CELLS are: DIE, create a new CELL, produce MATRIX, POLARIZE, and do nothing. POLARIZED CELLS have three options: DEPOLARIZE, reposition, or do nothing. At every decision point, the CELL uses the diagrammed logic to select and execute just one action. We iteratively refined ISEA1 to ISEA2. It consistently produced convex, cystic structures in addition to achieving the original set of targeted attributes.

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