I believe that there are more general approaches that deal with the issues discussed in this paper. The approach reported here has a serious shortcoming in dealing, for example, with sigmoidal saturation. Given that approximation theory, e.g. through Taylor series, can be used to create generic equations that describe the full class of biological saturation phenomena, what do we gain from going back to a less general formulation? For example, as far as I can tell, Sorribas et al (Biotechnology and Bioengineering Volume 97 Issue 5, Pages 1259 - 1277) have already proposed a formalism that deals with the issues address in this paper. That work is based on earlier work by Savageau (Savageau, M. A. (1976). "Biochemical Systems Analysis: A Study of Function and Design in Molecular Biology," Addison-Wesley, Reading, Mass.)
Theoretical Biology and Medical Modelling
A more general approach predates this report.
13 April 2010
I believe that there are more general approaches that deal with the issues discussed in this paper. The approach reported here has a serious shortcoming in dealing, for example, with sigmoidal saturation. Given that approximation theory, e.g. through Taylor series, can be used to create generic equations that describe the full class of biological saturation phenomena, what do we gain from going back to a less general formulation?
For example, as far as I can tell, Sorribas et al (Biotechnology and Bioengineering Volume 97 Issue 5, Pages 1259 - 1277) have already proposed a formalism that deals with the issues address in this paper. That work is based on earlier work by Savageau (Savageau, M. A. (1976). "Biochemical Systems Analysis: A Study of Function and Design in Molecular Biology," Addison-Wesley, Reading, Mass.)
Competing interests
I was a co-author in the paper I cite.