Table 5 MD studies of serum markers of inflammation and coagulation
From: Diet as prophylaxis and treatment for venous thromboembolism?
Author | Study Design | Population | Exposure variable | Outcome variable | Results |
|---|---|---|---|---|---|
Esposito [76] | RCT | Metabolic syndrome patients | MD | 1. Nutrient intake 2. endothelial function 3. lipid and glucose parameters 4. insulin sensitivity 5. hs-CRP 6. IL-6 7. IL-7 8. IL-18 | With MD 1. hs-CRP decreased (P = 0.01) 2. IL6 decreased 3. (P = 0.01) 4. Endothelial function improved (P < 0.001) 5. lipid and glucose parameters improved (P < 0.001) 6. decreased insulin resistance (P < 0.001) |
Mezzano [77] | RCT | Healthy volunteers | MD versus high fat diet | Fat content Fibrinogen factor VIIc factor VIIIc protein S | Fat content - MD: 27.3% - HFD: 39.9% With MD Fibrinogen reduced (P = 0.03) factor VIIc reduced (P = 0.034) factor VIIIc reduced (P = 0.0057) protein S increased (P = 0.013) |
Antonopoulou [75] | Observa-tional | Healthy volunteers and type 2 DM patients | MD | platelet aggregation in response to platelet aggregating factor or thrombin | Platelet activity reduced in both groups |
Chrysohoou [74] | Observa-tional | People in Greece | Adherence to MD comparing the highest and lowest tertile | CRP IL-6 Homocysteine WBCs | highest tertile participants averaged - 20% lower CRP levels (P = 0.015) - 17% lower interleukin-6 levels (P = 0.025) - 15% lower homocysteine levels (P = 0.031) - 14% lower white blood cell counts (P = 0.001) - 6% lower fibrinogen levels (P = 0.025) |