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Table 5 MD studies of serum markers of inflammation and coagulation

From: Diet as prophylaxis and treatment for venous thromboembolism?

Author Study Design Population Exposure variable Outcome variable Results
Esposito [76] RCT Metabolic syndrome patients MD 1. Nutrient intake
2. endothelial function
3. lipid and glucose parameters
4. insulin sensitivity
5. hs-CRP
6. IL-6
7. IL-7
8. IL-18
With MD
1. hs-CRP decreased (P = 0.01)
2. IL6 decreased
3. (P = 0.01)
4. Endothelial function improved (P < 0.001)
5. lipid and glucose parameters improved (P < 0.001)
6. decreased insulin resistance (P < 0.001)
Mezzano [77] RCT Healthy volunteers MD versus high fat diet Fat content
Fibrinogen
factor VIIc
factor VIIIc
protein S
Fat content
- MD: 27.3%
- HFD: 39.9%
With MD
Fibrinogen reduced (P = 0.03)
factor VIIc reduced (P = 0.034)
factor VIIIc reduced (P = 0.0057)
protein S increased (P = 0.013)
Antonopoulou [75] Observa-tional Healthy volunteers and type 2 DM patients MD platelet aggregation in response to platelet aggregating factor or thrombin Platelet activity reduced in both groups
Chrysohoou [74] Observa-tional People in Greece Adherence to MD comparing the highest and lowest tertile CRP
IL-6
Homocysteine
WBCs
highest tertile participants averaged
- 20% lower CRP levels (P = 0.015)
- 17% lower interleukin-6 levels (P = 0.025)
- 15% lower homocysteine levels (P = 0.031)
- 14% lower white blood cell counts (P = 0.001)
- 6% lower fibrinogen levels (P = 0.025)