Figure 4
From: Serotonin synthesis, release and reuptake in terminals: a mathematical model
Homeostatic effects of the autoreceptors. Panel A shows hows extracellular 5-HT (e 5ht) changes as the firing rate of the neuron varies above and below normal both with and without the autoreceptors. Panel B shows how extracellular 5-HT changes with the expression level of the SERTs both with and without the autoreceptors. s/s and l/l indicate the activities of the corresponding genotypes. Panel C shows how extracellular 5-HT changes with the activity level of TPH both with and without the autoreceptors. The activities of the R441 H and P449R polymorphims are indicated. In all cases, the autoreceptors reduce the effect of changes in firing rate and polymorphisms on extracellular 5-HT.