Figure 8

I _Ca,L & [Ca²⁺] _myo - comparison of model generated and experimental data in the negative voltage range. Figure 8: Model generated and experimentally obtained data from a rat ventricular myocyte clamped to voltages between -30 and 0 mv in steps of 10 mv. The holding potential used is -40 mv. Data is obtained from Dr. Philip. T. Palade's lab. (A) I_Ca,Linvoked by negative clamp voltages in the range of -30 mv to 0 mv in steps of 10 mv. The pulse duration used is 100 ms. (B) Peak I_Ca,Ldependance on clamp voltage. (C) Global cytosolic calcium transients [Ca²⁺] _myo at negative (-30 mv ≤ v ≤ 0 mv) clamp voltages. The pulse duration used is 100 ms (D) Peak cytosolic calcium transients ([Ca²⁺] _myo ) dependence on clamp voltages. Solid traces are the model-generated results and dotted lines represent the data