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Figure 8 | Theoretical Biology and Medical Modelling

Figure 8

From: Propagation of kinetic uncertainties through a canonical topology of the TLR4 signaling network in different regions of biochemical reaction space

Figure 8

Experimentally reported and simulated transcriptional readouts. Black dashed trajectories indicate experimentally reported transcriptional activation profiles during a short time window of 120 minutes. Color-coded trajectories stand for simulated trajectories obtained from an extensive exploration of biochemical reaction space by means of Monte Carlo simulations and a pseudo-random search algorithm. Experimental data encompassed only 6 time points that were sampled in cell cultures during the time window of 120 minutes. We performed non-linear interpolation in order to infer the relative expression levels of each gene every minute during the time window. This strategy allowed us to further constrain our simulations.

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