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Figure 4 | Theoretical Biology and Medical Modelling

Figure 4

From: Safe uses of Hill's model: an exact comparison with the Adair-Klotz model

Figure 4

Equilibrium state similarity measure for h = 2. The contour plot that depicts how long time limit of δ∞ = limt→∞δ(t) depends on the dissociation constants K1 = β1/α1 and K2 = β2/α2; δ∞ = f(K0, K1, K2). For a fixed pair (K1, K2) the Hill model dissociation constant K0 = β/α is optimized to make δ∞ as large as possible, making the Hill's model dissociation constant dependent on Adair-Klotz's model dissociation constants in a well defined way; K0 = g(K1, K2) leading to the function δ∞ = f(g(K1, K2), K1, K2) = δmax(K1, K2) that is depicted in the plot.

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