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Table 2 Model Values for Key Indices and Variables in Control and LVDD Cases

From: Modeling left ventricular diastolic dysfunction: classification and key indicators

Parameter Control Impaired Relaxation Restrictive Filling Pseudo-Normalization
e LV,SPT (t) normal normal altered altered normal normal altered altered
Contractility normal increased normal increased normal increased normal increased
λ DAP DAM (1/ml) 0.05 0.05 0.05 0.05 0.1 0.1 0.1 0.1
λ LV (1/ml) 0.025 0.025 0.025 0.025 0.05 0.05 0.05 0.05
E LV,ES (mmHg/ml) 3.5 5.6 3.5 5.6 3.5 5.6 3.5 5.6
LVEDP (mmHg) 10.5 9.5 16.0 17.0 23.3 21.4 25.0 25.0
MSAP (mmHg) mHg)(mmHg) 96.6 98.4 91.5 91.3 89.0 90.6 84.9 85.3
CVP (mmHg) 2.4 2.6 1.4 1.4 0.2 0.6 -0.6 -0.6
HR (beats/min) 55.2 53.9 60.2 60.6 63.8 61.4 68.2 68.1
CO (l/min) 4.9 5.2 3.9 3.9 3.5 3.9 3.0 3.0
LVSV (ml) 89.4 96.0 64.7 63.9 55.3 62.7 43.5 44.1
LVEF 0.72 1.4 0.68 0.76 0.65 0.76 0.63 0.72
LVET (sec) 0.28 0.31 0.26 0.27 0.29 0.31 0.27 0.28
RVSV (ml) 89.1 95.8 64.5 63.7 54.5 61.9 43.3 43.7
RVEF 0.62 0.81 0.49 0.48 0.44 0.47 0.37 0.36
RVET (sec) 0.38 0.37 0.33 0.33 0.27 0.30 0.22 0.22
P AO2 (mmHg) 105.0 104.3 106.5 106.6 108.1 106.2 108.9 108.5
P ACO2 (mmHg) 39.3 39.6 38.0 37.7 37.2 37.5 36.3 36.3
P TO2 (mmHg) 42.5 43.4 37.2 36.9 33.5 35.8 29.5 29.5
P TCO2 (mmHg) 45.4 45.2 46.8 46.9 47.8 47.2 48.4 48.4
P BO2 (mmHg) 37.4 37.4 37.2 37.2 36.9 37.2 36.2 36.3
P BCO2 (mmHg) 45.3 45.2 45.8 45.9 46.2 46.1 46.2 46.2
A-V O2 (T) 4.4% 4.4% 5.9% 6.0% 7.1% 6.2% 9.0% 8.9%
A-V CO2 (T) -1.9% -1.9% -2.4% -2.4% -2.7% -2.5% -3.1% -3.1%
A-V O2 (B) 5.1% 5.1% 5.5% 5.5% 5.9% 5.6% 6.2% 6.2%
A-V CO2 (B) -0.4% -0.4% -0.8% -0.8% -0.9% -0.8% -1.1% -1.1%
F HRv 0.54 0.54 0.51 0.51 0.50 0.51 0.47 0.39
F HRs 0.28 0.27 0.33 0.33 0.35 0.34 0.39 0.39
F con 0.40 0.38 0.45 0.46 0.49 0.47 0.53 0.53
F vaso 0.54 0.51 0.62 0.62 0.64 0.62 0.70 0.69
F b 0.41 0.41 0.39 0.39 0.38 0.38 0.36 0.36
F c 0.17 0.17 0.16 0.16 0.15 0.16 0.14 0.14
F cc 0.53 0.53 0.54 0.54 0.55 0.55 0.55 0.55
  1. Values calculated for several indices and variables associated with the ventricles, systemic circulation and gas transport. These values are displayed for control conditions (normal heart), and for the three possible forms of LVDD (impaired active relaxation (IR) alone, increased passive stiffness (R) alone, and combined impaired relaxation and increased stiffness (PN)) without (ELV,ES = 3.5) and with (ELV,ES = 5.6) increased systolic contractility. All are averaged over one respiratory cycle. FHRv, FHRs, Fcon, Fvaso are mean baroreceptor frequencies affecting heart rate (vagal and sympathetic components), contractility, and vasomotor tone. PAO2, PTO2 and PBO2 are arterial, systemic venous, and jugular venous partial O2 pressures; likewise PACO2, PTCO2 and PBCO2 are partial CO2 pressures.