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Archived Comments for: Site-specific dose-response relationships for cancer induction from the combined Japanese A-bomb and Hodgkin cohorts for doses relevant to radiotherapy

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  1. Fit parameters for RECTUM

    Uwe Schneider, University of Zürich and Hirslanden Medical Center

    23 March 2012

    Dear Reader,
    Upon the publication of the manuscript titled ¿Site-specific dose-response relationships for cancer induction from the combined Japanese A-bomb and Hodgkin cohorts for doses relevant to radiotherapy,¿ it was found that EAR for Rectum from the Dores data was obtained (for agex=30 and agea=70) by using the temporal patterns of ¿all solid cancers¿ (parameters¿ game = -0.024 and gamaa = 2.38). However, it would be more realistic to use the temporal patterns for ¿Colon¿ (parameters¿ game = -0.056 and gamaa = 6.9). A re-calculation of EAR for ¿rectum¿ resulted in 12.5 instead of 1.53. As a consequence the EAR model fitted the ¿rectum¿ data with the following results:
    - Linear model: not converging
    - Full model: alpha=0.033, R=0.56, CV=2.4E-5
    - Bell shape: alpha=0.031, R=0, CV=1.9E-3
    - Full recovery: alpha=0.065, R=1, CV=7.5E-4

    We are sorry that this error was not observed at an earlier stage.
    Best regards,
    Uwe Schneider

    Competing interests

    None declared

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