Figure 3
From: Modeling invasion of metastasizing cancer cells to bone marrow utilizing ecological principles
Competition among two species: Cancer cells as the superior species. The red (dash) line indicates the superior species (cancer cells); the green (solid) line indicates the inferior species (HSC). (A) Superior species (cancer cells) has a colonization rate of β1 = 0.2, mortality rate μ1 = 0.1 time-1, and initial density = 0.0001. Inferior species (HSC) has a colonization rate β2 = 0.8, mortality rate μ2 = 0.1 time-1, and initial density = 0.5. The * of the density curve of the inferior species is obtained from Eq. 2. (B) The superior species (cancer cells) has initial density = 0.01, and the inferior species (HSC) has initial density = 0.85; all other conditions remained the same as in (A). (C) The inferior species (HSC) has initial density = 0.84 and colonization rate β2 = 0.6 time-1 ; all other conditions remained the same as in (A).