Table 2 Parameters and values used in intracellular signal transduction modules.

Bistable switch

Michaelis Menten constants

V_f

27 hr^-1

[6]

Michaelis Menten constants

V_r

0.459 hr^-1

[6]

Michaelis Menten constants

K_m1

100

[6]

Michaelis Menten constants

K_m2

0.01

[6]

Kinetic parameter mediating feedback strength

k_fb

2.927 hr^-1

[6]

Basal parameter in the bistable switch

p

0.7

Estimated

Parameter mediating input regulation in the bistable switch

q

0.3(ng/(10⁵ cells))^-1

Estimated

Monostable switch

Kinetic parameter reflecting the time scale of the response

k

0.432 hr^-1

Estimated

Associated constant

k_h

1 ng/(10⁵ cells)

Estimated

Hill coefficient

n

10

Estimated

R₁ protein activation rate

k_f

3.6 hr^-1

Estimated

R₁ protein degradation rate

k_r

0.144 hr^-1

Estimated

R₁ Threshold for apoptosis switch

R₁,_th

0.9

Estimated