Table 1 Parameters which change in the three scenarios; parameters values pre-surgery and for each hypothesis are show
From: Bariatric surgery and T2DM improvement mechanisms: a mathematical model
Pre-surgery | Post-surgery | Definition | |||
|---|---|---|---|---|---|
Hypothesis | |||||
Parameters | Lower-intestinal (GLP-1) | Upper-intestinal (Anti-incretin) | Ghrelin | ||
Nmeals | 1 | 1 | 1 | 1 | meal n.1 is simulated |
M1 | 500 | 500 | 500 | 500 | amount of glucose in the meal |
ATmin | 25 | 25 | 0 | 25 | plasmatic anti-incretin basal level |
Amax | 500 | 500 | 0 | 500 | maximum amount of anti-incretin |
HTmin | 150 | 150 | 150 | 0 | plasmatic ghrelin basal level |
Hmax | 300 | 300 | 300 | 0 | maximum amount of ghrelin |
Hmin | 29.6 | 29.6 | 29.6 | 0 | minimum amount of ghrelin |
kds | 0.02 | 0 | 0.02 | 0.02 | transfer rate from stomach to duodenum |
kls | 0 | 0.02 | 0 | 0 | transfer rate from stomach to ileum |
kld | 0.02 | 0 | 0.02 | 0.02 | transfer rate from duodenum to ileum |
kgd | 0.02 | 0 | 0.02 | 0.02 | transfer rate from duodenum to plasma glucose |