Figure 3

Second phase to estimate the effects on radiosensitivity of variable concentrations of mAb EGFr inhibitor in Head and Neck cell lines. Surviving fraction curves corresponding to the daily concentrations of mAb from pharmacokinetics curves[20] are obtained by interpolation. The following concentrations of EGFr mAb inhibitor are obtained: 100, 61, 37, 22 and 13 nM. The corresponding polynomial regression curves provide α/β = 5, 9, 12, 14 and 15 Gy (with α = 0.2 Gy^-1), with respect to untreated cells with α/β = 16 Gy (α = 0.2 Gy^-1).