Figure 2

(a) Chromatin regions that share similar natural frequencies are clustered into a proximal region within the cell nucleus. The different colored loops represent different chromatin loops and the blue dots represent chromatin regions functioning as oscillators. These regions may share similar genomic and epigenetic features or bind to certain chromatin-associated protein complexes. They function as chromatin organizers in the nucleus. The green circular region, which contains many of the juxtaposed chromatin oscillators, represents a chromatin oscillation cluster. (b) Schematic illustration of how different chromatin loops are wired through different chromatin oscillation clusters. These COCs further cluster with each other on the basis of average frequencies, forming higher-order chromatin clusters.