Figure 1
From: The biochemistry of acetaminophen hepatotoxicity and rescue: a mathematical model
Acetaminophen metabolism. Blue boxes indicate substrates: APAP, acetaminophen; APAP-S, APAP-sulfonate; APAP-G, APAP-glucoronidate; NAPQI, N-acetyl-p-benzoquinone imine; NAPQI-COV, covalent binding of NAPQI; NAPQI-GSH, NAPQI conjugated with glutathione; PAPS, 3’-Phosphoadenosine-5’-phosphosulfate; GSH, glutathione. The light orange ovals indicate the enzymes that catalyze reactions: SULT, sulfotransferase; UGT, glucuronosyltransferase; CYP, cytochrome P-450 oxidase; GST, glutathione S-transferase.