Figure 6
From: The biochemistry of acetaminophen hepatotoxicity and rescue: a mathematical model
Glutathione depletion and covalent binding. Panel A shows model results. The blue curve shows the liver GSH concentration as a percentage of normal (left scale) 2 hours after the a dose of APAP as a function of dose size. The red curve shows the concentration of covalent binding of NAPQI (right scale) scaled to equal 2 at extremely high doses for easy comparison with the results of Mitchell et al.[6]. Panel B shows the comparable experimental results redrawn from[6] for the same two quantities.