Table 1 Base case flow and metabolism parameters
From: A physiologically-based flow network model for hepatic drug elimination III: 2D/3D DLA lobule models
Parameter | Characteristic (SI) Unit | STARS Unit |
|---|---|---|
Sinusoid Porosity Ï• sin | 0.7854 | 0.7854 |
Sinusoid Permeability K sin | 1.125 μm2 | 1.140 Darcya |
Sinusoid Effective Diffusion D sin | 4.2 × 10−10 m2/s | 2.5 × 10−4 cm2/min |
Tissue Porosity Ï• tis | 0.2382 | 0.2382 |
Tissue Permeability K tis | 7.35 × 10−2 μm2 | 7.45 × 10−2 Darcy |
Tissue Effective Diffusion D tis | 4.2 × 10−11 m2/s | 2.5 × 10−5 cm2/min |
Maximum Rate v max b | 0.06 μM/min | 1.08 × 10−9 mole fraction/min |
Half Saturation Constant K m b | 10.0 μM | 1.8 × 10−7 mole fraction |
Linear Rate v max/K m b | 6.0 × 10−3 min−1 | 6.0 × 10−3 min−1 |
Blood Viscosity μ | 3.5 × 10−3 Pa-sec | 3.5 cpoise |