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Table 1 Base case flow and metabolism parameters

From: A physiologically-based flow network model for hepatic drug elimination III: 2D/3D DLA lobule models

Parameter Characteristic (SI) Unit STARS Unit
Sinusoid Porosity ϕ sin 0.7854 0.7854
Sinusoid Permeability K sin 1.125 μm2 1.140 Darcya
Sinusoid Effective Diffusion D sin 4.2 × 10−10 m2/s 2.5 × 10−4 cm2/min
Tissue Porosity ϕ tis 0.2382 0.2382
Tissue Permeability K tis 7.35 × 10−2 μm2 7.45 × 10−2 Darcy
Tissue Effective Diffusion D tis 4.2 × 10−11 m2/s 2.5 × 10−5 cm2/min
Maximum Rate v max b 0.06 μM/min 1.08 × 10−9 mole fraction/min
Half Saturation Constant K m b 10.0 μM 1.8 × 10−7 mole fraction
Linear Rate v max/K m b 6.0 × 10−3 min−1 6.0 × 10−3 min−1
Blood Viscosity μ 3.5 × 10−3 Pa-sec 3.5 cpoise
  1. a 1 Darcy = 0.9869 μm2 in engineering permeability units
  2. b PAC kinetic elimination Michaelis-Menten parameters converted from Vaclavikova et al. [17], their Table 4