Fig. 1
From: Modeling multi-mutation and drug resistance: analysis of some case studies
The schematic view of the system interactions. The system includes 4 types of cells: normal cells (N), wild tumor cells (T), mutated tumor cells (TM), and drug resistant tumor cells (TR). The population of normal, wild tumor and mutated tumor cells decreases as they interact with the drug. As the wild tumor cells divide, they can create mutated tumor cells or resistant tumor cells. As the mutated tumor cells interact with the drug, they can partially die and partially be transformed to resistant cells induced by the utilized anti-cancer drug