From: Theory of synergistic effects: Hill-type response surfaces as ‘null-interaction’ models for mixtures
Assumptions | Properties | ||||
---|---|---|---|---|---|
Approach | Eq. | u _{ max } | Slopes γ | Pure a.i. limit | Sham compliance |
Bliss / Colby | 13 | Unequal | γ _{ a }≠γ _{ b } | Ok | No |
Loewe / CA | 14 | Equal | γ _{ a }=γ _{ b } | Ok | Yes |
GCA | 18 | Unequal | γ=1 | Ok | Yes |
Chou _{ exc } | 19 | Equal | γ _{ a }=γ _{ b } | Ok | Yes |
Chou _{ nonex } | 20 | Equal | γ _{ a }=γ _{ b } | Ok | No |
Greco | 17 | Equal | γ _{ a }≠γ _{ b } ^{a} | (Ok)^{b} | (Yes)^{b} |
Minto / Fidler | 21 | Variable | Variable | (Ok)^{c} | (Yes)^{c} |
Hill | 5, 7 | Variable | Variable | Ok | Yes |