Table 1 Characteristics of theoretical models describing mixtures
From: Theory of synergistic effects: Hill-type response surfaces as ‘null-interaction’ models for mixtures
Assumptions | Properties | ||||
|---|---|---|---|---|---|
Approach | Eq. | u max | Slopes γ | Pure a.i. limit | Sham compliance |
Bliss / Colby | Unequal | γ a ≠γ b | Ok | No | |
Loewe / CA | Equal | γ a =γ b | Ok | Yes | |
GCA | Unequal | γ=1 | Ok | Yes | |
Chou exc | Equal | γ a =γ b | Ok | Yes | |
Chou nonex | Equal | γ a =γ b | Ok | No | |
Greco | Equal | γ a ≠γ b a | (Ok)b | (Yes)b | |
Minto / Fidler | Variable | Variable | (Ok)c | (Yes)c | |
Hill | Variable | Variable | Ok | Yes | |