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Table 3 Literature values for known parameters and uncertainties (if known) in kinetics model

From: On the utility of a compartmental population kinetics model of intestinal epithelial stem cell proliferation and differentiation

Parameter Calculated Value and Units References
N c (250 cells per crypt) x (2 crypts per villus) = 500 crypt cells per crypt/villus unit (see text for details of calculation) Crosnier  [8], Stappenbeck [9]
N v 3500 villus cells per crypt/villus unit Crosnier  [8]
N 4000 total cells per crypt/villus unit (N = N c +N v ) ––––––––––––––––
k 1 = α 1 day-1 Barker [1]
β 1.75 ± 0.25 day-1 Barker [35]
λ 5 (1/21 days) = 0.047 day-1 Roth [33]
CBC 0 (5 ± 1 cells per crypt) x (2 crypts per villus) = 10 ± 2 CBC per crypt/villus unit Marshman [2]
EEC t → ∞ (0.01) x N = 40 per crypt/villus unit Sternini [6],
Gunawardene [5]
TC t → ∞ (0.004) x N = 16 per crypt/villus unit Gerbe [10]
GC t → ∞ (0.085 ± 0.015) x N = 340 ± 60 per crypt/villus unit Gregorieff [4]
PC t → ∞ 40 ± 10 cells per crypt x (2 crypts per villus) = 80 ± 20 PC per crypt/villus unit Spradling [7]
TAC t → ∞ 155 ± 5 cells per crypt x (2 crypts per villus) = 310 ± 10 TAC per crypt/villus unit Potten [3]
EC t → ∞ 2844 ± 72 (baseline scenario, see text for details of calculation) ––––––––––––––––
EC t → ∞ 2848 ± 72 (fast scenario, see text for details of calculation) ––––––––––––––––