Table 3 Literature values for known parameters and uncertainties (if known) in kinetics model

N _c

(250 cells per crypt) x (2 crypts per villus) = 500 crypt cells per crypt/villus unit (see text for details of calculation)

Crosnier  [8], Stappenbeck [9]

N _v

3500 villus cells per crypt/villus unit

Crosnier  [8]

N

4000 total cells per crypt/villus unit (N = N _c +N _v )

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k ₁ = α

1 day^-1

Barker [1]

β

1.75 ± 0.25 day^-1

Barker [35]

λ ₅

(1/21 days) = 0.047 day^-1

Roth [33]

CBC ₀

(5 ± 1 cells per crypt) x (2 crypts per villus) = 10 ± 2 CBC per crypt/villus unit

Marshman [2]

EEC _{t → ∞}

(0.01) x N = 40 per crypt/villus unit

Sternini [6],

Gunawardene [5]

TC _{t → ∞}

(0.004) x N = 16 per crypt/villus unit

Gerbe [10]

GC _{t → ∞}

(0.085 ± 0.015) x N = 340 ± 60 per crypt/villus unit

Gregorieff [4]

PC _{t → ∞}

40 ± 10 cells per crypt x (2 crypts per villus) = 80 ± 20 PC per crypt/villus unit

Spradling [7]

TAC _{t → ∞}

155 ± 5 cells per crypt x (2 crypts per villus) = 310 ± 10 TAC per crypt/villus unit

Potten [3]

EC _{t → ∞}

2844 ± 72 (baseline scenario, see text for details of calculation)

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EC _{t → ∞}

2848 ± 72 (fast scenario, see text for details of calculation)

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