Table 1 List of the model parameters

I ₀

Basal transcription rate by transcription factors, which are not affected by RA (M/h)

1.6 × 10⁻¹² − 1.6 × 10⁻⁹

[73]

k _dm

TMR degradation rate (1/h)

0.256

[71]

k _trans

Translation rate(1/h)

1–10,000

[73]

k _dp

TM degradation rate (1/h)

0.0845

[72]

IC _TMR

TMR initial concentration (M)

1.6 × 10⁻¹¹ − 1.6 × 10⁻⁸

[73, 74]

IC _TM

TM initial concentration (M)

1.65 × 10⁻⁵ − 2.14 × 10⁻⁵

[40]

I _max

Maximal transcription rate of the TM gene (M/h)

1.6 × 10⁻¹² − 1.6 × 10⁻⁹

[73]

k _d1

Equilibrium dissociation constant of RA binding to retinoic acid receptor (M)

8 × 10⁻⁹

[75]

k _d2

Equilibrium dissociation constant of DNA-transcription factor complex (M)

15 × 10⁻⁹

[76]

[REC_1t]

Total concentration (M) of the specific transcription factor which can activate the TM gene transcription

1 × 10⁻¹¹ − 1 × 10⁻⁶

Unknown. A large range is used.