Skip to main content

Table 1 List of the model parameters

From: Analysis of the role of thrombomodulin in all-trans retinoic acid treatment of coagulation disorders in cancer patients

Parameters Description Range Reference
I 0 Basal transcription rate by transcription factors, which are not affected by RA (M/h) 1.6 × 10−12 − 1.6 × 10−9 [73]
k dm TMR degradation rate (1/h) 0.256 [71]
k trans Translation rate(1/h) 1–10,000 [73]
k dp TM degradation rate (1/h) 0.0845 [72]
IC TMR TMR initial concentration (M) 1.6 × 10−11 − 1.6 × 10−8 [73, 74]
IC TM TM initial concentration (M) 1.65 × 10−5 − 2.14 × 10−5 [40]
I max Maximal transcription rate of the TM gene (M/h) 1.6 × 10−12 − 1.6 × 10−9 [73]
k d1 Equilibrium dissociation constant of RA binding to retinoic acid receptor (M) 8 × 10−9 [75]
k d2 Equilibrium dissociation constant of DNA-transcription factor complex (M) 15 × 10−9 [76]
[REC1t] Total concentration (M) of the specific transcription factor which can activate the TM gene transcription 1 × 10−11 − 1 × 10−6 Unknown. A large range is used.