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Fig. 5 | Theoretical Biology and Medical Modelling

Fig. 5

From: MiStImm: an agent-based simulation tool to study the self-nonself discrimination of the adaptive immune response

Fig. 5

Immune response in the ERS model. a Normal immune response against a repeated infection. First infection was injected at the 300th day and the second infection was injected at the 310th day. Both infections are the same type (number of cells =350, mean waiting time between two divisions =60). The second infection was eliminated faster due to the existence of B cell memory. Horizontal axis: time (day) from conception. Vertical axis: number of cells/molecules. b Division of weak/intermediate/strong kind of T and B cells in the same simulation showed in (a). Horizontal axis: time (day) from conception. Vertical axis: number of divisions. c Autoimmunity caused by the lack of negative selection of B cells: number of self cells decreases rapidly. Horizontal axis: time (day) from conception. Vertical axis: number of cells/molecules

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