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Table 4 Estimates and the 95% confidence intervals for parameters of multistate transition-specific parametric models

From: Modelling HIV disease process and progression in seroconversion among South Africa women: using transition-specific parametric multi-state model

Variables Transition 1: Normal to Mild,
TR(95% CI)
Transition 2: Mild to Advanced,
TR (95% CI)
Transition 3: Advanced to Severe,
TR (95% CI)
Transition 4: Severe to Advanced,
TR (95% CI)
Transition 5: Advanced to Mild,
TR (95% CI)
Transition 6: Mild to Normal,
TR (95% CI)
Viral Load 1.26 (1.19, 1.33)a 1.27 (1.20, 1.35)a 1.32 (1.18, 1.48)a 1.16 (0.98, 1.37) 0.95 (0.89, 0.98)a 0.94 (0.89, 0.99)b
Anaemia: Yes 1.01 (0.91, 1.13) 1.09 (0.99, 1.20) 1.23 (1.03, 1.48) 0.71 (0.55, 0.92)a 0.94 (0.82, 1.06) 0.92 (0.82, 1.03)
TB: No 1.11 (0.83, 1.50) 1.19 (0.98, 1.44) 1.07 (0.69, 1.68) 1.15 (1.09, 1.22)a 0.92 (0.73, 1.16) 1.50 (1.13, 2.01)a
Marital Status: Married 1.01 (0.88, 1.16) 0.80 (0.70, 0.90)a 0.96 (0.75, 1.23) 0.91 (0.66, 1.27) 0.92 (0.80, 1.07) 0.96 (0.84, 1.10)
Marital Status: Many Partners 1.12 (0.89, 1.42) 0.74 (0.59, 1.09) 0.78 (0.53, 1.14) 0.71 (0.65, 0.78)a 0.92 (0.72, 1.17) 0.98 (0.75, 1.26)
Education: Grade 9–10 0.74 (0.61, 0.89)a 0.95 (0.80, 1.12) 1.15 (0.87, 1.51) 1.09 (0.69, 1.73) 0.97 (0.79, 1.18) 1.06 (0.87, 1.29)
Education: Grade ≥ 11 0.82 (0.69, 0.99)a 0.84 (0.72, 1.04) 0.81 (0.63, 1.04) 1.02 (0.68, 1.51) 0.96 (0.81, 1.15) 1.10 (0.93, 1.32)
Contraceptive use: No 1.03 (0.91, 1.16) 0.99 (0.89, 1.11) 1.02 (0.83, 1.25) 0.99 (0.73, 1.34) 0.85 (0.74, 0.97)a 0.89 (0.78, 1.01)
Age_Cat: ≤20 years 1.08 (0.95, 1.22) 1.04 (0.92, 1.18) 0.99 (0.78, 1.24) 1.12 (0.78, 1.60) 1.15 (0.99, 1.34) 1.03 (0.91, 1.17)
Age_Cat: 21–39 years 1.11 (0.89, 1.38) 0.87 (0.68, 1.11) 0.74 (0.44, 1.24) 0.90 (0.83, 0.98)b 1.42 (0.96, 1.94) 1.33 (0.94, 1.65)
Sex while Drunk: No 1.04 (0.89, 1.21) 0.88 (0.75, 1.04) 0.76 (0.60, 0.98)a 1.07 (1.01, 1.12)a 0.88 (0.74, 1.04) 1.01 (0.85, 1.21)
Weight 0.99 (0.98, 1.01)a 0.99 (0.97, 1.02)a 1.01 (0.99, 1.01) 1.01 (1.00, 1.02)a 1.00 (0.99, 1.01) 1.00 (0.99, 1.01)
Independence Score 0.95 (0.94, 0.96)a 0.99 (0.97, 1.01) 0.97 (0.94, 0.99)a 0.99 (0.94, 1.03) 1.00 (0.99, 1.02) 1.01 (0.99, 1.02)
Social relationship score 0.98 (0.96, 0.99)a 0.99 (0.97, 1.01) 0.96 (0.93, 0.99)a 0.99 (0.94, 1.07) 1.00 (0.98, 1.02) 0.96 (0.95, 1.02)
Physical Health Score 1.13 (0.92, 1.16) 1.03 (1.00, 1.06) 1.01 (0.97, 1.07) 1.09 (1.02, 1.16)a 1.01 (0.97, 1.03) 1.07 (1.04, 1.10)a
Psychological Score 0.90 (0.88, 0.93)a 0.95 (0.93, 0.97)a 0.95 (0.90, 0.99)a 0.94 (0.88, 1.01) 0.95 (0.92, 1.03) 0.94 (0.92, 1.04)
Liver Abn Comp 0.97 (0.94, 1.02) 0.99 (0.95, 1.04) 1.01 (0.94, 1.08) 1.00 (0.89, 1.12) 0.93 (0.87, 0.98)a 1.03 (0.99, 1.08)
RBC indices 0.98 (0.94, 1.03) 0.95 (0.91, 0.99)b 0.99 (0.91, 1.08) 0.96 (0.85, 1.07) 0.94 (0.89, 1.00) 1.04 (1.00, 1.10)
Hb and Haematocrit Comp 0.97 (0.92, 1.01) 0.99 (0.95, 1.04) 1.01 (0.94, 1.10) 1.04 (0.93, 1.16) 1.01 (0.96, 1.07) 1.04 (0.99, 1.09)
Granulocytes comp 0.95 (0.92, 1.00) 0.95 (0.90, 1.01) 0.99 (0.91, 1.08) 1.01 (0.88, 1.15) 1.08 (1.03, 1.14)a 1.05 (1.00, 1.10)
Mononuclear comp 0.87 (0.83, 1.09) 0.82 (0.78, 0.87)a 0.82 (0.74, 0.91)a 1.12 (0.98, 1.27) 1.14 (1.08, 1.18)a 1.18 (1.12, 1.23)a
Eosinophils comp 1.01 (0.97, 1.05) 0.97 (0.93, 1.01) 1.01 (0.92, 1.11) 0.97 (0.89, 1.05) 0.98 (0.93, 1.03) 1.00 (0.96, 1.04)
Electrolyte Comp 0.98 (0.94, 1.03) 1.01 (0.97, 1.06) 1.05 (0.97, 1.14) 0.94 (0.85, 1.05) 1.04 (0.99, 1.10) 1.04 (0.99, 1.08)
Protein Comp 0.96 (0.91, 1.01) 1.03 (0.98, 1.08) 0.99 (0.90, 1.09) 0.93 (0.83, 1.05) 1.03 (0.97, 1.09) 1.00 (0.96, 1.04)
Intercept 0.40 (0.22, 0.71)a 0.43 (0.27, 0.70)a 0.23 (0.08, 0.60)a 0.21 (0.05, 0.92)a 1.01 (0.57, 1.76) 0.35 (0.20, 0.61)a
  1. Keys:- (a) the coefficient is significant at α = 0.05, (b) the coefficient is a significant at α = 0.01, Reference category: Age [> 40 years], education [≤ Grade 8], marital status [Single], Sex while Drunk [Yes], Contraceptive use [Yes], Anemia [No], and TB [Yes]